The expression of CD25 has significant clinical implications. It is a marker for T-cell activation and is involved in autoimmune diseases, cancers, and transplant rejection. Elevated levels of CD25 can indicate the presence of leukemia or lymphoma, particularly in conditions like adult T-cell leukemia/lymphoma (ATLL). Conversely, reduced CD25 expression on Tregs may be linked to autoimmune disorders, as these cells are crucial for maintaining immune tolerance.
