What are the Key Mechanisms Behind Collective Cell Movement?
Several mechanisms drive collective cell movement:
Cell-Cell Adhesion: Adhesion proteins like cadherins and integrins play a pivotal role in maintaining the integrity of the cell group. Polarity and Signaling: Cells within a moving group often establish front-rear polarity, guided by signaling pathways such as the Wnt and Notch pathways. Mechanical Forces: Cells generate and respond to mechanical forces via the cytoskeleton, enabling coordinated movement. Extracellular Matrix Interaction: The extracellular matrix provides both a substrate for movement and signals that regulate cell behavior.
