The sum of the individual scores determines the overall grade of the tumor:
Grade 1 (Low grade): Total score 3-5 Grade 2 (Intermediate grade): Total score 6-7 Grade 3 (High grade): Total score 8-9
Grade 1 tumors are well-differentiated, Grade 2 tumors are moderately differentiated, and Grade 3 tumors are poorly differentiated. Higher grades are associated with more aggressive behavior and a poorer prognosis.
