How is Fixed Drug Eruption Diagnosed through Histology?
Diagnosis of FDE through histology involves identifying the characteristic features mentioned above. A biopsy taken from the edge of a lesion typically reveals a band-like infiltrate of lymphocytes that obscures the dermo-epidermal junction, along with necrotic keratinocytes. The presence of these features, combined with the clinical history of recurrent lesions at the same site following drug exposure, supports the diagnosis of FDE.
