How does Fixed Drug Eruption Differ from Other Drug Reactions Histologically?
FDE can be differentiated from other drug-induced skin reactions histologically by its unique pattern. Unlike erythema multiforme, which may show similar epidermal necrosis, FDE tends to have more localized and recurrent lesions. Furthermore, the presence of a dense, band-like lymphocytic infiltrate in FDE is distinct from the more diffuse infiltrate seen in other conditions, such as drug-induced hypersensitivity syndrome (DIHS).
