Upon binding to its ligands like BDNF, the TrkB receptor undergoes dimerization and autophosphorylation on specific tyrosine residues. This autophosphorylation triggers downstream signaling pathways, including the PI3K/Akt pathway, the MAPK/ERK pathway, and the PLC-γ pathway. These pathways collectively contribute to cell survival, growth, and synaptic plasticity.
