Despite its advantages, celloidin has some limitations:
Time-consuming: The embedding process is more time-consuming compared to paraffin embedding, requiring several days to weeks for complete infiltration and hardening. Handling and Safety: Celloidin solutions are flammable and require careful handling and storage. Additionally, the use of chemicals like chloroform presents health hazards. Section Thickness: Sections obtained from celloidin-embedded tissues are generally thicker (10-20 micrometers) compared to paraffin sections, which can range from 3-5 micrometers.
