How Does MPG Interact with Other Cellular Pathways?
MPG does not function in isolation; it interacts with multiple cellular pathways to maintain genomic stability. It collaborates with other DNA repair proteins in the BER pathway, such as XRCC1, PARP1, and DNA polymerase β. Moreover, MPG is involved in the cellular response to oxidative stress and can be regulated by signaling pathways such as p53 and NF-κB. These interactions highlight the intricate network of pathways that work together to protect cells from DNA damage.
