Given its role in DNA repair, MPG is of significant clinical interest. Deficiencies or mutations in MPG can lead to genomic instability, contributing to the development of various cancers and other diseases. Conversely, overexpression of MPG has been observed in certain cancers, suggesting that it might play a role in tumorigenesis or chemoresistance. Understanding the regulation and function of MPG in different tissues can provide valuable insights into potential therapeutic targets for treating diseases associated with DNA damage.
