Dentinogenesis can be divided into two primary stages:
1. Predentin Formation: Odontoblasts first secrete predentin, an unmineralized organic matrix composed mainly of collagen. This phase involves the synthesis and assembly of collagen fibrils and other non-collagenous proteins.
2. Mineralization: The second stage involves the deposition of hydroxyapatite crystals within the predentin matrix, leading to its mineralization. This process transforms predentin into mature dentin. The mineralization front progresses in a wave-like manner, and the rate of dentin formation can vary depending on the developmental stage and physiological conditions.
