homologous recombination

How Does Homologous Recombination Work?

The process of homologous recombination involves several steps:
1. Double-Strand Break Recognition: The cell detects a double-strand break in the DNA.
2. Resection: The ends of the break are processed to generate single-stranded DNA.
3. Homology Search: The single-stranded DNA invades a homologous DNA duplex to form a displacement loop (D-loop).
4. Strand Exchange and Synthesis: DNA polymerase synthesizes new DNA using the homologous strand as a template.
5. Resolution: The D-loop is resolved, and the DNA strands are ligated to complete the repair.

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