What are the Implications of Defective Homologous Recombination?
Defects in homologous recombination can lead to a variety of genetic disorders and diseases. For example: - Cancer: Mutations in genes such as BRCA1 and BRCA2 are linked to an increased risk of breast and ovarian cancers. - Fanconi Anemia: This genetic disorder is characterized by bone marrow failure and increased cancer risk, often resulting from defective DNA repair mechanisms. - Ataxia-Telangiectasia: A condition caused by mutations in the ATM gene, which plays a role in the DNA damage response.
