What Role Do Proteins Play in Homologous Recombination?
Several key proteins facilitate homologous recombination: - RAD51: This protein is essential for the homology search and strand invasion steps. - BRCA1 and BRCA2: These tumor suppressor genes are involved in the repair of DNA damage and play a role in the regulation of RAD51. - MRE11-RAD50-NBS1 (MRN) Complex: This complex is crucial for the initial recognition and processing of DNA breaks.
