MALDI-IMS is a technique that combines histological imaging with mass spectrometric analysis. A tissue section is coated with a matrix that aids in ionization. A laser beam then desorbs and ionizes the molecules in the sample. The ions are analyzed by the mass spectrometer, generating a mass spectrum for each pixel of the tissue section. By compiling these spectra, a molecular image of the tissue is created, highlighting the distribution of specific molecules.
