How Does Degradation Affect Histological Analysis?
Degradation can obscure cellular details and tissue architecture, making it challenging to identify pathological changes or normal structures. For instance, in histopathology, degraded tissues might show artifactual changes that mimic disease processes, leading to misdiagnosis. Degradation also affects immunohistochemistry, as degraded epitopes may not bind effectively to antibodies, resulting in weak or false-negative staining.
