To prevent degradation, several steps must be taken: - Immediate Fixation: Tissue samples should be fixed as soon as possible after collection. - Optimal Fixative Use: Using the appropriate fixative in the correct concentration and volume is essential. - Controlled Storage: Samples should be stored under optimal conditions, such as refrigeration or in a fixative solution. - Careful Handling: Minimizing physical trauma during sample collection and preparation can reduce mechanical degradation.