What are the Signs of Degradation in Histological Samples?
Signs of degradation include: - Loss of Cellular Detail: Cells may appear swollen, shrunken, or ruptured. - Disruption of Tissue Architecture: Tissues may become fragmented or show irregular contours. - Staining Artifacts: Uneven or non-specific staining patterns can indicate chemical degradation. - Presence of Autolytic Changes: Such as nuclear pyknosis, karyorrhexis, or karyolysis, where the nucleus shows signs of self-digestion.
