Decreased GFR is often associated with histological changes in the kidney: - Thickening of the glomerular basement membrane, which can reduce filtration efficiency. - Loss or damage to podocytes, compromising the integrity of the filtration barrier. - Mesangial cell proliferation, which can lead to reduced capillary surface area available for filtration. - Tubulointerstitial fibrosis, indicating chronic damage and scarring in the kidney tissue.
