Several conditions can lead to decreased GFR, including: - Diabetic nephropathy: Characterized by GBM thickening and mesangial expansion. - Hypertension: Can cause damage to the glomerular capillaries. - Glomerulonephritis: Inflammation of the glomeruli, often resulting in impaired filtration. - Chronic kidney disease (CKD): Progressive loss of kidney function and structural changes in the renal tissue.
