Wnt proteins function by binding to [receptors](https://) on the cell surface, primarily [Frizzled receptors](https://) and co-receptors like [LRP5/6](https://). Upon binding, they initiate a signaling cascade that can follow one of the three primary pathways: the [canonical Wnt/β-catenin pathway](https://), the non-canonical planar cell polarity pathway, and the non-canonical Wnt/Ca²⁺ pathway.
