Exocytosis inhibitors work by interfering with the molecular machinery involved in vesicle fusion. For instance, botulinum toxins cleave SNARE proteins such as synaptobrevin, SNAP-25, and syntaxin, which are essential for the docking and fusion of vesicles with the plasma membrane. By disrupting these proteins, botulinum toxins prevent the release of neurotransmitters and other molecules, effectively inhibiting exocytosis.
