What are the histological characteristics of PSEN2 mutations?
Mutations in PSEN2 are linked to early-onset familial Alzheimer’s disease (EOFAD). Histologically, these mutations often result in increased amyloid plaque formation and neurofibrillary tangles within brain tissues. These pathological features can be observed through histological staining techniques such as Congo red and Thioflavin S staining, which highlight amyloid deposits.
