Histological diagnosis of prion diseases often involves brain biopsy or autopsy samples. Special staining techniques such as Hematoxylin and Eosin (H&E) staining are commonly used to visualize the spongiform changes. Immunohistochemistry can be employed to detect the accumulation of prion protein (PrPSc), which is the misfolded and infectious form of the normal cellular prion protein (PrPC).
