Yes, fibroblasts exhibit remarkable phenotypic plasticity. They can differentiate into myofibroblasts, a more contractile form of fibroblasts that express alpha-smooth muscle actin (α-SMA). Myofibroblasts are crucial for wound contraction and closure. Fibroblasts can also transdifferentiate into other cell types under specific conditions, such as adipocytes or osteoblasts, highlighting their versatility.
