Fibroblasts have several critical functions, including: - Synthesis of Collagen: They produce collagen fibers, the most abundant proteins in the extracellular matrix, providing tensile strength to tissues. - Extracellular Matrix Production: Fibroblasts synthesize various components of the extracellular matrix, such as glycosaminoglycans, proteoglycans, and fibronectin. - Wound Healing: They play a pivotal role in wound healing by migrating to the wound site, proliferating, and producing new extracellular matrix to replace damaged tissue. - Tissue Repair and Remodeling: Fibroblasts are involved in the continuous process of tissue maintenance, repair, and remodeling.
