Are There Any Protective Mechanisms Against NSAID-Induced Damage?
Several strategies can mitigate the histological damage caused by NSAIDs:
COX-2 Selective Inhibitors: These drugs specifically target the COX-2 enzyme, sparing COX-1 and thus reducing GI side effects. Proton Pump Inhibitors (PPIs): Often prescribed alongside NSAIDs to reduce gastric acid secretion and protect the gastric lining. Misoprostol: A synthetic prostaglandin E1 analog that can help maintain the protective mucosal barrier in the GI tract.
