What Are the Histological Changes in the GI Tract Due to NSAIDs?

The chronic use of NSAIDs can induce several histological changes in the GI tract:

Gastric Mucosa: Reduced mucus secretion can lead to erosion of the gastric mucosa, characterized by a loss of the superficial epithelial layer.
Inflammation: Inflammatory cells such as neutrophils and lymphocytes may infiltrate the gastric tissues, leading to gastritis.
Ulceration: Severe cases can result in the formation of ulcers, with deep breaches in the mucosal and submucosal layers.