What Are the Histological Changes in the GI Tract Due to NSAIDs?
The chronic use of NSAIDs can induce several histological changes in the GI tract:
Gastric Mucosa: Reduced mucus secretion can lead to erosion of the gastric mucosa, characterized by a loss of the superficial epithelial layer. Inflammation: Inflammatory cells such as neutrophils and lymphocytes may infiltrate the gastric tissues, leading to gastritis. Ulceration: Severe cases can result in the formation of ulcers, with deep breaches in the mucosal and submucosal layers.
