Yes, there are several alternative markers and methods for detecting cellular senescence:
1. p16INK4a and p21: These are cell cycle inhibitors that are upregulated in senescent cells and can be detected using immunohistochemistry. 2. Senescence-associated Heterochromatin Foci (SAHF): These are specialized chromatin structures found in senescent cells and can be visualized using specific DNA staining techniques. 3. DNA Damage Markers: Senescent cells often exhibit DNA damage, which can be detected using markers such as γ-H2AX.
