What are the Challenges in Promoting Axonal Growth?
Several challenges exist in promoting axonal growth, especially in the CNS:
1. Inhibitory Environment: The presence of inhibitory molecules such as myelin-associated inhibitors and chondroitin sulfate proteoglycans in the CNS can hinder axonal regeneration.
2. Intrinsic Growth Capacity: Adult neurons often have a reduced intrinsic capacity for growth compared to developing neurons.
3. Scar Formation: After injury, the formation of a glial scar can create a physical and chemical barrier to axonal growth.
