Why are KRAS Mutations Important in Cancer Diagnosis and Treatment?

KRAS mutations are significant because they can inform both the diagnosis and treatment of various cancers. Their presence can help pathologists determine the type and aggressiveness of the tumor. Additionally, KRAS mutations can influence treatment decisions, as tumors harboring these mutations may not respond well to certain targeted therapies, such as EGFR inhibitors. Understanding the status of KRAS mutations in a tumor can thus guide personalized treatment strategies.