immunosuppressive tumor microenvironment

Which cells in the TME are involved in immunosuppression?

Several types of cells within the TME are known to contribute to immunosuppression:
1. Regulatory T Cells (Tregs): These cells suppress the activation and proliferation of effector T cells.
2. Myeloid-Derived Suppressor Cells (MDSCs): These cells inhibit T cell activation and promote tumor growth.
3. Tumor-Associated Macrophages (TAMs): Generally polarized towards an M2 phenotype, these macrophages support tumor growth and suppress anti-tumor immunity.
4. Cancer-Associated Fibroblasts (CAFs): These fibroblasts create a supportive stroma and secrete factors that inhibit immune cell function.

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