How does the extracellular matrix (ECM) influence tumor immunosuppression?
The extracellular matrix (ECM) provides structural support to tissues but also plays a significant role in cell signaling. In the TME, the ECM is often remodeled to create a physical barrier that impedes the infiltration of immune cells into the tumor. Additionally, components of the ECM can bind to growth factors and cytokines, further modulating the immune response.
