Thrombospondin is widely distributed throughout the body. It is produced by various cell types, including platelets, endothelial cells, smooth muscle cells, and fibroblasts. This protein is prominently present in the ECM of tissues undergoing repair or remodeling, such as during wound healing and in the development of the vascular system. Additionally, thrombospondin can be found in high concentrations in the bone, cartilage, and skin.
