Ankyrin G is ubiquitously expressed but is particularly abundant in neuronal cells, where it is found at the axon initial segment (AIS) and nodes of Ranvier. It is also present in epithelial cells at the basolateral membrane and in the heart, where it localizes to intercalated discs and T-tubules. The diverse localization of Ankyrin G underscores its multifunctional role in cellular architecture and function.
