What are the Clinical Implications of Ankyrin G Dysfunction?

Dysfunction or mutations in Ankyrin G can have significant clinical implications. In neurons, it can lead to epilepsy, autism spectrum disorders, and intellectual disabilities. In epithelial cells, it may contribute to cancer progression and metastasis by disrupting cell adhesion. In the heart, Ankyrin G mutations are associated with arrhythmias and heart failure. Understanding the role of Ankyrin G in these contexts is crucial for developing targeted therapies for these conditions.