How is Ankyrin G Associated with Cardiac Function?
In the heart, Ankyrin G is localized at intercalated discs and T-tubules, where it plays a role in the organization of ion channels and the maintenance of electrical coupling between cardiac cells. This is essential for synchronized contraction and efficient heart function. Mutations in the ANK3 gene, which encodes Ankyrin G, have been linked to cardiac arrhythmias and other cardiovascular diseases.
