neural stem cell niche

What Signals Regulate Neural Stem Cell Behavior?

Several signaling pathways are crucial in regulating NSC behavior within the niche:
Notch signaling maintains NSC quiescence and prevents differentiation.
Wnt signaling promotes NSC proliferation and differentiation.
Sonic Hedgehog (Shh) signaling is involved in NSC proliferation and maintenance.
Bone Morphogenetic Proteins (BMPs) inhibit NSC proliferation and promote differentiation.

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