The neural stem cell niche undergoes significant changes with aging and in the context of various diseases:
Aging: The number of NSCs declines, along with changes in niche cell composition and signaling, leading to reduced neurogenesis. Neurodegenerative Diseases: Conditions like Alzheimer’s disease and Parkinson’s disease can disrupt niche dynamics, impairing NSC function. Injury: Brain injuries can activate NSCs and niche cells to promote repair, although the efficacy of this response varies.
