How Do Neural Stem Cells Interact with Their Niche?
NSCs interact with their niche through a variety of mechanisms:
Cell-Cell Interactions: Direct contact with other niche cells, such as ependymal cells and astrocytes, influences NSC fate. Cell-Matrix Interactions: NSCs interact with the ECM through integrins and other receptors, which provide signals for proliferation and differentiation. Soluble Factors: Growth factors, cytokines, and neurotransmitters are secreted by niche cells and influence NSC behavior.
