In the context of CNS pathology, GFAP is involved in the process of reactive gliosis, where astrocytes become reactive in response to CNS injury. This reactivity is characterized by an upregulation of GFAP and other structural proteins, leading to the formation of a glial scar. While this glial scar can help contain the damage, it can also impede the regeneration of neuronal connections, making it a double-edged sword in CNS repair processes.
