GFAP is commonly detected using immunohistochemistry (IHC). In this technique, specific antibodies that recognize GFAP are used to bind to the protein in tissue sections. These antibodies are often tagged with a fluorescent dye or an enzyme that produces a color reaction, allowing for the visualization of GFAP under a microscope. This method is widely used in both research and clinical settings to identify and study astrocytes in various conditions.