What is the Clinical Significance of Preprocollagen?
Abnormalities in preprocollagen synthesis or modification can lead to various connective tissue disorders. For instance, Ehlers-Danlos syndrome arises from defects in collagen processing enzymes, leading to hyperelasticity and fragility of the skin. Similarly, scurvy results from vitamin C deficiency, impairing the hydroxylation of proline and lysine, leading to weakened collagen fibers and bleeding gums.
