GFAP has several clinical applications, particularly in the diagnosis of neurological diseases. Elevated levels of GFAP can be indicative of astrocytosis, a condition where there is an abnormal increase in the number of astrocytes due to CNS injury or diseases such as Alzheimer's, multiple sclerosis, and brain tumors. GFAP is also used as a biomarker in the diagnosis of Alexander disease, a rare genetic disorder affecting white matter in the brain.
