What Role Does DIT Play in Thyroid Hormone Biosynthesis?
DIT plays a pivotal role in the biosynthesis of thyroid hormones. The process begins with the iodination of tyrosine residues within thyroglobulin in the presence of the enzyme thyroid peroxidase and hydrogen peroxide. This results in the formation of MIT and DIT. Subsequent coupling reactions between MIT and DIT or between two DIT molecules lead to the formation of T3 and T4, respectively.
