Impaired synthesis of DIT can lead to thyroid dysfunctions. For instance, deficiencies in iodine, a key component in the formation of DIT, can result in insufficient production of T3 and T4, leading to hypothyroidism. Conversely, excessive iodine can disrupt the normal synthesis and regulation of thyroid hormones, potentially resulting in hyperthyroidism. Both conditions can have significant physiological effects, including metabolic imbalances, growth abnormalities, and cardiovascular issues.
