What Role Do Peripheral Membrane Proteins Play in Disease?
Dysfunction or misregulation of peripheral membrane proteins is implicated in various diseases. For instance: 1. Cancer: Abnormal signaling pathways involving peripheral membrane proteins can lead to uncontrolled cell growth and cancer. 2. Neurodegenerative Diseases: Proteins involved in synaptic signaling and cytoskeletal stability, when dysfunctional, can contribute to diseases like Alzheimer's. 3. Cardiovascular Diseases: Peripheral membrane proteins that regulate cellular adhesion and signaling in vascular endothelial cells are critical for maintaining vascular health. Dysregulation can lead to atherosclerosis and other cardiovascular conditions.
