Paromomycin is an aminoglycoside antibiotic derived from the bacterium *Streptomyces rimosus var. paromomycinus*. It has been used predominantly to treat various parasitic infections, including amoebiasis, giardiasis, and leishmaniasis. Its mechanism of action involves binding to the 16S ribosomal RNA of the 30S ribosome, thereby inhibiting protein synthesis in susceptible organisms.