IL-1Rs are part of the immunoglobulin superfamily and share structural similarities with other cytokine receptors. They typically consist of three extracellular immunoglobulin-like domains, a single transmembrane domain, and an intracellular domain that facilitates signal transduction. The extracellular domains are responsible for binding IL-1, while the intracellular domain interacts with adaptor proteins to propagate the signal inside the cell.
