How are Interleukin 1 Receptors Involved in Disease?
Dysregulation of IL-1R signaling is implicated in various inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Overactivation of IL-1R signaling can lead to chronic inflammation and tissue damage. Conversely, deficiencies in IL-1R signaling can impair immune responses, making individuals more susceptible to infections.
