What are the Differences Between IL-1R1 and IL-1R2?
IL-1R1 and IL-1R2 have distinct roles in IL-1 signaling. IL-1R1 is the primary signaling receptor, capable of initiating the full signaling cascade upon binding IL-1. In contrast, IL-1R2 acts as a decoy receptor; it binds IL-1 with high affinity but lacks the intracellular signaling domain, thereby sequestering IL-1 and preventing it from activating IL-1R1.
